The pair were granted a wild card after Murray pulled out of the singles due to his failure to regain full fitness.

The Russian looked out of sorts early on Centre Court as he lost the first set.

Defending Wimbledon champion Carlos Alcaraz made a shaky start against unseeded Australian Aleksandar Vukic but moved through the gears to seal a 7-6(5) 6-2 6-2 victory and power into the third round on Wednesday.

Playing with a support on his right leg following a minor operation less than four weeks ago that cut short his French Open, the 37-year-old made a solid start and drew first blood in a marathon fourth game.

Czech Vondrousova, who became the first unseeded woman to lift the title last year, earned a far less welcome accolade after a 6-4 6-2 defeat by Spain's Jessica Bouzas Maneiro.

Osaka returned to the tour this year after 15 months of maternity leave for her daughter who turns one on Tuesday.

The Spanish third seed was taken to a tie-break in the opening set and trailed 2-0 against his unheralded opponent in the second but held his nerve to win 7-6 (7/3), 7-5, 6-2.

Medvedev, a semi-finalist last year, hit 16 aces in his 6-3, 6-4, 6-2 win over Aleksandar Kovacevic of the United States.

Alcaraz, 21, beat Novak Djokovic to the title a year ago and has since taken his Grand Slam haul to three after winning the French Open earlier this month and despite being seeded three will be favourite to rack up number four.

The Serbian is bidding for a record 25th Grand Slam title.

Novak Djokovic proclaimed himself "pain free" after defeating Daniil Medvedev in an exhibition match on Friday ahead of Wimbledon.

Novak Djokovic will play at Wimbledon after being named in the draw on Friday, despite concerns over his fitness following his withdrawal from the French Open.

The 21-year-old overcame a forearm issue to bag his first French Open title, emulating greats including Rafa Nadal, Roger Federer, Novak Djokovic and Andre Agassi with major wins on clay, hard and grass courts.

The Italian is determined to consolidate his position at the top.

Alcaraz, also the reigning Queen's champion, was beaten 7-6 (7/3), 6-3 by home favourite Jack Draper in the biggest win of the British number one's career.

"Novak Djokovic and Dusan Lajovic have fulfilled the conditions according to ATP ranking and confirmed their participation at the Summer Olympic Games in Paris 2024", the Serbian committee said on their web-site.

Three-time Grand Slam runner up Ons Jabeur said on Monday she will sit out this summer's Paris Olympics to avoid further injury to her knee.

Andy Murray was on Sunday named as one of the four British singles players for the Paris Olympics, which will be his fifth Summer Games.

Spanish tennis chiefs announced Wednesday that 22-time Grand Slam winner Nadal and newly crowned French Open champion Carlos Alcaraz would be part of the country's team at the Games next month.

World number two Alcaraz last weekend won his first Roland Garros title on the clay in Paris, where the Olympic tournament will take place from July 27 to August 4.